Skip Navigation

This Article
Right arrow Print PDF (623K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (256)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Thamann, T. J.
Right arrow Articles by Rich, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thamann, T. J.
Right arrow Articles by Rich, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1981, Vol. 9, No. 20 5443-5458
© 1981

CHEMISTRY

The high salt form of poly(dG-dC)·poly(dG-dC) is left-handed Z-DNA: Raman spectra of crystals and solutions

Thomas J. Thamann, Richard C. Lord, Andrew H.J. Wang and Alexander Rich

Spectroscopy Laboratory and Departments of Chemistry and Biology, Massachusetts Institute of Technology Cambridge, MA 02139, USA

Received July 22, 1981. The laser-Raman spectra of crystalline d(CpGpCpGpCpG) and of aqueous poly(dG-dC)·poly(dG-dC) in high salt (4M NaCl) and low salt (0.lM NaCl) solutions have been measured and compared. The spectra of the crystal and the high-salt solution show a striking congruence, which indicates clearly that the high-salt form of the aqueous polymer has the left-handed Z-DNA structure of the crystalline oligomer. These two spectra differ substantially from that of the low-salt form of the polymer, which has been found previously to have spectral characteristics of the B-form of DNA. The high salt spectrum shows a unique line due to guanine residues at 625 cm-1 which should be useful for qualitative and possibly quantitative assessment of the amount of Z-structure present in a sample of DNA.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Biophys. JHome page
H. Zhang, H. Yu, J. Ren, and X. Qu
Reversible B/Z-DNA Transition under the Low Salt Condition and Non-B-Form PolydApolydT Selectivity by a Cubane-Like Europium-L-Aspartic Acid Complex
Biophys. J., May 1, 2006; 90(9): 3203 - 3207.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A Nordheim, W. Hao, G. Wogan, and A Rich
Salt-induced conversion of B-DNA to Z-DNA inhibited by aflatoxin B1
Science, March 25, 1983; 219(4591): 1434 - 1436.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.