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Nucleic Acids Research, 1981, Vol. 9, No. 21 5659-5669
© 1981

CHEMISTRY

The B->Z transition of poly (dG–dC).poly(dG–dC) modified by some platinum derivatives

Bernard Malfoy, Brighte Hartmann and Marc Leng

Centre de Biophysique Moleculaire, C.N.R.S., 1A, avenue de la Recherche Scientifique 45045 Orleans Cedex, France

Received September 25, 1981. Poly(dG–dC).poly(dG–dC) was modified by chlorodiethylenetriamino platinum(II) chloride, cis-dichlorodiammine platinum (II) and trans-dichlorodiammineplatinum (II), respectively. The conformation of these modified poly(dG–dC). poly(dG–dC) was studied by circular dichroism. In 4 M Na+, the circular dichroismspectra of poly(dG–dC) dien-Pt (0 ≤ rb, ≤ 0.2) are similar (rb is the amount of bound platinum per base). It is concluded that the conformation of these polymers belongs to the Z-family. Dien-Pt complexes stabilize the Z form. The midpoint of the Z -> B transition of poly(dG–dC)dien-Pt(0.12) is at 0.2 M NaCl. Moreover another B -> Z transition is observed at lower salt concentration (midpoint at 6 mM NaCl). In 1 mM phosphate buffer, the stability of Z-poly(dG-dC)dien-Pt(0.12) is greatly affected by the presence of small amounts of EDTA. Poly(dG-dC). poly(dG–dC) modified by ais-Pt and trans-Pt complexes do not adopt the Z-form even in high salt concentration.


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