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Nucleic Acids Research, 1981, Vol. 9, No. 22 6103-6114
© 1981

MOLECULAR BIOLOGY

The sequence of human serum albumin cDNA and its expression in E. coli

Richard M. Lawn, John Adelman, Susan C. Bock, Arthur E. Franke, Catherine M. Houck, Richard Najarian, Peter H. Seeburg and Karen L. Wion

Department of Molecular Biology, Genentech Inc. 460, Point San Bruno Boulevard, South San Francisco, CA 94080, USA

Received August 31, 1981. A recombinant plasmid has been constructed which contains the mature protein coding region of the human serum albumin (HSA) gene. Bacteria containing this plasmid synthesize HSA protein under control of the E. coli trp promoter-operator. The DNA sequence and predicted protein sequence of HSA were determined from the cDNA plasmid and are compared to existing data obtained from direct protein sequencing. The DNA sequence predicts a mature protein of 585 amino acids preceded by a 24 amino acid "prepro’ peptide.


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