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Nucleic Acids Research, 1981, Vol. 9, No. 23 6591-6599
© 1981

MOLECULAR BIOLOGY

Some characteristics of apurinic sites in single- and double-stranded biologically active {phi}X174 DNA

M.V.M. Lafleur, J. Woldhuis and H. Loman

Physics Laboratory of the Vrije Universiteit, Department of Biophysics de Boelelaan 1081, 1081 HV Amsterdam, The Netherlands

Received September 8, 1981. With biologically active DNA of the bacteriophage {phi}X174, both single and double-stranded, some physico-chemical and biological parameters of the depurination reaction are studied. It is shown that in single-stranded DNA each apurinic site is lethal, while in double-stranded RFI-DNA only about 5% of these sites are lethal. Furthermore it is concluded that the apurinic sites are formed at different rates in single- and double-stranded DNA and also the conversion into breaks of the apurinic sites is different for both forms of DNA.


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