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Nucleic Acids Research, 1981, Vol. 9, No. 24 6723-6734
© 1981

MOLECULAR BIOLOGY

A novel rearrangement of the human ßlike globin gene cluster

R.J. Trent, D.K. Bowden*, J.M. Old, J.S. Wainscoat, J.B. Clegg and D.J. Weatherall

MRC Molecular Haematology Unit, Nuffield Department of Clinical Medicine, John Radcliffe Hospital Headington, Oxford 0X3 9DU, UK *Vila Base Hospital Porta Vila, Vanuatu

Received October 28, 1981. The first example of a duplication involving the human ß-like globin genes has been characterised in DNA from a native of Vanuatu. Restriction endonuclease mapping has shown that a 5 kb insert of DNA in the {gamma}-{delta}-ß gene cluster is due to duplication of the G{gamma}-globin gene and results in a new rearrangement ‘5'-{varepsilon}-G{gamma}-G{gamma}-A{gamma}-{delta}-ß-3’


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