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Nucleic Acids Research, 1981, Vol. 9, No. 24 7033-7040
© 1981

MOLECULAR BIOLOGY

Computer programs to assist in high resolution thermal denaturation and circular dichroism studies on nucleic acids

Thomas C. Goodman*, Stephen C. Hardies**, Carlos Cortez+ and Wolfgang Hillen{dagger}

University of Wisconsin, Department of Biochemistry, College of Agricultural and Life Sciences Madison, WI 53706, USA

*To whom correspondence about these programs should be addressed. In requesting programs, individuals should specify which programs they would like to receive and whether they require a source listing or floppy disk.

**Present Address: University of North Carolina, School of Medicine, Department of Bacteriology and Immunology, Chapel Hill, N.C. 27514

+Present Address: Shinar Digital, Inc., 128 W. Main Street, Evansville, W.I. 53536

{dagger}Present Address: Institut für Organische Chemie und Biochemie, Technische Hochschule Darmstadt, Petersenstr. 22, D-6100 Darmstadt, FRG.

Received September 15, 1981. Computer programs are described that direct the collection, processing, and graphical display of numerical data obtained from high resolution thermal denaturation (1–3) and circular dichroism (4) studies. Besides these specific applications, the programs may also be useful, either directly or as programming models, in other types of spectrophotometric studies employing computers, programming languages, or instruments similar to those described here (see Materials and Methods).


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