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Nucleic Acids Research, 1981, Vol. 9, No. 3 731-741
© 1981

CHEMISTRY

Bacterial synthesis of a novel human leukocyte interferon

Elizabeth Yelverton*, David Leung*, Phillip Week**, Patrick W. Gray* and David V. Goeddel*

*Departments of Molecular Biology South San Francisco, CA 94080, USA **Biology, Genentech Inc., 460 Point San Bruno Boulevard South San Francisco, CA 94080, USA

Received November 11, 1980. A novel human leukocyte interferon cDNA clone (LeIF B) was identifiedin a cDNA library prepared using polyadenylated mRNA of a myeloblastoid cell line. The nucleotide sequence of LeIF B differs significantly from other published leukocyte interferon cDNA sequences. An expression plasmid was constructed which directs the synthesis in E. coli of 8x107 interferon units per liter of culture. LeIF B exhibits markedly different specificities from another bacterially synthesized humanleukocyte interferon, LeIF A.


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