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Nucleic Acids Research, 1981, Vol. 9, No. 6 1365-1382
© 1981

MOLECULAR BIOLOGY

The complete nucleotide sequence of mouse immunoglobulin {gamma}2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer

Yuriko Yamawaki-Kataoka, Takashi Miyata* and Tasuku Honjo

Department of Genetics, Osaka University Medical School Osaka *Department of Biology, Faculty of Science, Kyushu University Fukuoka 812, Japan

Received February 4, 1981. We have determined the complete nucleotide sequence (1990 base pairs) of mouse immunoglobulin {tau}2a gene, and compared it with the sequences of other {tau} subclass genes so far sequenced, i.e. {tau}i and {tau}2b genes. Divergence of the nucleotide sequences between a compared pair of the {tau} genes varies extensively among different segments of the gene. For example, comparison of the {tau}2a and {tau}2b genes has revealed a remarkable homology in a long continuous segment (about 900 bases) that covers from the 3' portion of the first intervening sequence to the third intervening sequence. However, there is no particular segment of the {tau} gene that is conserved universally among the three {tau} genes. These findings suggest that, during their evolution, segments of the {tau} genes had been scrambled between different subclass genes through recombinations within intervening sequences, thus providing further evidence for the intervening sequence-mediated domain transfer hypothesis. We have discussed several possible phylogenic trees which can explain the difference of divergence in various segments of the {tau} genes.


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