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Nucleic Acids Research, 1981, Vol. 9, No. 6 1499-1518
© 1981

MOLECULAR BIOLOGY

Coding capacity of complementary DNA strands

A. Casino, M. Cipollaro+, A.M. Guerrini, G. Mastrocinque++, A. Spena and V. Scarlato

International Institute of Genetics and Biophysics Naples, Italy +III^ Servizio di Analisi, 2nd Medical School, University of Naples Italy ++Istituto Elettrotecnico, Facoltà di Ingegneria, University of Naples Italy

Received November 25, 1980. A Fortran computer algorithm has been used to analyze the nucleotide sequence of several structural genes. The analysis performed on both coding and complementary DNA strands shows that whereas open reading frames shorter than 100 codons are randomly distributed on both DNA strands, open reading frames longer than 100 codons ("virtual genes") are significantly more frequent on the complementary DNA strand than on the coding one.

These "virtual genes" were further investigated by looking at intron sequences, splicing points, signal sequences and by analyzing gene mutations. On the basis of this analysis coding and complementary DNA strands of several eukaryotic structural genes cannot be distinguished. In particular we suggest that the complementary DNA strand of the human {varepsilon}-globin gene might indeed code for a protein.


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