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Nucleic Acids Research, 1981, Vol. 9, No. 7 1559-1569
© 1981

MOLECULAR BIOLOGY

The nucleotide sequence of the initiation region of the ribosomal transcription unit from mouse

René Bach1, Ingrid Grummt2,+ and Bernard Allet3

1Départment de Biologie Animale 154, Route de Malagnou, CH-1224 Chene-Bougeries, Switzerland 2Max-Planck-Institut für Biochemie D-8033 Martinsried, GFR 3Biogen, S.A. Route de Troinex 3 CH-1227 Caruge, Switzerland

+To whom correspondence should be addressed: Institut für Biochemie, Röntgenring 11, D-8700 Würzburg, GFR

Received February 17, 1981. The 5' end of 45S pre-rRNA has been located on a cloned rDNA fragment from mouse by r-loop mapping and the nuclease S1 protection technique. 45S pre-rRNA could be shown to represent the primary transcript of the ribosomal genes because 5' polyphosphate termini have been detected by an enzymatic assay. The sequence of about 1100 nucleotides surrounding the initiation site for ribosomal RNA transcription has been determined. Features of this region ofthe ribosomal DNA will be discussed. A comparison of the nucleotide sequence with corresponding areas of ribosomal genes from other eukaryotes does not reveal significant homology in the region of transcription initiation.


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