Nucleic Acids Research Advance Access published online on November 13, 2007
Nucleic Acids Research, doi:10.1093/nar/gkm1001
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The BioGRID Interaction Database: 2008 update
1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, M5G 1X5, 2Department of Molecular Genetics, University of Toronto, Toronto, M5S 1A8, Canada 3Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA and 4Wellcome Trust Sanger Institute, Cambridge CB10 1HH, UK
*To whom correspondence should be addressed. Tel: 416 586 8371; Fax: 416 586 8869; Email: tyers{at}mshri.on.ca
Received September 20, 2007. Revised October 19, 2007. Accepted October 22, 2007.
The Biological General Repository for Interaction Datasets (BioGRID) database (http://www.thebiogrid.org) was developed to house and distribute collections of protein and genetic interactions from major model organism species. BioGRID currently contains over 198 000 interactions from six different species, as derived from both high-throughput studies and conventional focused studies. Through comprehensive curation efforts, BioGRID now includes a virtually complete set of interactions reported to date in the primary literature for both the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe. A number of new features have been added to the BioGRID including an improved user interface to display interactions based on different attributes, a mirror site and a dedicated interaction management system to coordinate curation across different locations. The BioGRID provides interaction data with monthly updates to Saccharomyces Genome Database, Flybase and Entrez Gene. Source code for the BioGRID and the linked Osprey network visualization system is now freely available without restriction.
Present address: Mike Tyers, Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.
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