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Nucleic Acids Research Advance Access originally published online on November 19, 2007
Nucleic Acids Research 2008 36(Database issue):D923-D928; doi:10.1093/nar/gkm1039
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Nucleic Acids Research, 2008, Vol. 36, Database issue D923-D928
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

VIOLIN: vaccine investigation and online information network

Zuoshuang Xiang1,2,3, Thomas Todd1,2, Kim P. Ku4, Bethany L. Kovacic5, Charles B. Larson5, Fang Chen1,2, Andrew P. Hodges3, Yuying Tian6, Elizabeth A. Olenzek4, Boyang Zhao5, Lesley A. Colby1, Howard G. Rush1, Janet R. Gilsdorf7, George W. Jourdian8,9,10 and Yongqun He1,2,3,*

1Unit for Laboratory Animal Medicine, 2Department of Microbiology and Immunology, 3Center for Computational Medicine and Biology, 4College of Literature, Science, and the Arts, 5Department of Engineering, University of Michigan, 6Medical School Information Services, 7Department of Pediatrics and Communicable Diseases, 8Department of Internal Medicine, 9Department of Biological Chemistry and 10Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109, USA

*To whom correspondence should be addressed. Tel: 734 615 8231; Fax: 734 936 3235; Email: yongqunh{at}umich.edu

Received August 15, 2007. Revised October 30, 2007. Accepted October 31, 2007.

Vaccines are among the most efficacious and cost-effective tools for reducing morbidity and mortality caused by infectious diseases. The vaccine investigation and online information network (VIOLIN) is a web-based central resource, allowing easy curation, comparison and analysis of vaccine-related research data across various human pathogens (e.g. Haemophilus influenzae, human immunodeficiency virus (HIV) and Plasmodium falciparum) of medical importance and across humans, other natural hosts and laboratory animals. Vaccine-related peer-reviewed literature data have been downloaded into the database from PubMed and are searchable through various literature search programs. Vaccine data are also annotated, edited and submitted to the database through a web-based interactive system that integrates efficient computational literature mining and accurate manual curation. Curated information includes general microbial pathogenesis and host protective immunity, vaccine preparation and characteristics, stimulated host responses after vaccination and protection efficacy after challenge. Vaccine-related pathogen and host genes are also annotated and available for searching through customized BLAST programs. All VIOLIN data are available for download in an eXtensible Markup Language (XML)-based data exchange format. VIOLIN is expected to become a centralized source of vaccine information and to provide investigators in basic and clinical sciences with curated data and bioinformatics tools for vaccine research and development. VIOLIN is publicly available at http://www.violinet.org


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