Skip Navigation



Nucleic Acids Research Advance Access published online on December 18, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn1005
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (624K) Freely available
Right arrow Screen PDF (190K) Freely available
Right arrow Supplementary Data
Right arrowOA All Versions of this Article:
37/3/825    most recent
gkn1005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Pu, S.
Right arrow Articles by Wodak, S. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pu, S.
Right arrow Articles by Wodak, S. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Computational Biology

Up-to-date catalogues of yeast protein complexes

Shuye Pu1,*, Jessica Wong1, Brian Turner1, Emerson Cho1 and Shoshana J. Wodak1,2,3

1Molecular Structure and Function Program, Hospital for Sick Children, Toronto ON, M5G 1X8, 2Department of Biochemistry University of Toronto, 1 Kings College Circle, Toronto ON, M5S 1A8 and 3Department of Molecular Genetics, University of Toronto, 1 Kings College Circle, Toronto ON, M5S 1A8, Canada

*To whom correspondence should be addressed. Tel: +1 416 813 8899; Fax: +1 416 813 8755; Email: shuyepu{at}sickkids.ca

Received October 14, 2008. Revised November 28, 2008. Accepted December 1, 2008.

Gold standard datasets on protein complexes are key to inferring and validating protein–protein interactions. Despite much progress in characterizing protein complexes in the yeast Saccharomyces cerevisiae, numerous researchers still use as reference the manually curated complexes catalogued by the Munich Information Center of Protein Sequences database. Although this catalogue has served the community extremely well, it no longer reflects the current state of knowledge. Here, we report two catalogues of yeast protein complexes as results of systematic curation efforts. The first one, denoted as CYC2008, is a comprehensive catalogue of 408 manually curated heteromeric protein complexes reliably backed by small-scale experiments reported in the current literature. This catalogue represents an up-to-date reference set for biologists interested in discovering protein interactions and protein complexes. The second catalogue, denoted as YHTP2008, comprises 400 high-throughput complexes annotated with current literature evidence. Among them, 262 correspond, at least partially, to CYC2008 complexes. Evidence for interacting subunits is collected for 68 complexes that have only partial or no overlap with CYC2008 complexes, whereas no literature evidence was found for 100 complexes. Some of these partially supported and as yet unsupported complexes may be interesting candidates for experimental follow up. Both catalogues are freely available at: http://wodaklab.org/cyc2008/.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
J. L. Y. Koh, H. Ding, M. Costanzo, A. Baryshnikova, K. Toufighi, G. D. Bader, C. L. Myers, B. J. Andrews, and C. Boone
DRYGIN: a database of quantitative genetic interaction networks in yeast
Nucleic Acids Res., October 30, 2009; (2009) gkp820v1.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.