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Nucleic Acids Research Advance Access published online on April 28, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn228
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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CRISPRcompar: a website to compare clustered regularly interspaced short palindromic repeats

Ibtissem Grissa1,*, Gilles Vergnaud1,2 and Christine Pourcel1

1Univ. Paris-Sud 11, CNRS, UMR8621, Institut de Génétique et Microbiologie, 91405 Orsay and 2DGA/D4S - Mission pour la Recherche et l’Innovation Scientifique, 7, rue des Mathurins, 00470 Armées, France

*To whom correspondence should be addressed. Tel: +33 1 69 15 30 01; Fax: +33 1 69 15 66 78; Email: ibtissem.grissa{at}igmors.u-psud.fr

Received January 25, 2008. Revised April 6, 2008. Accepted April 11, 2008.

Clustered regularly interspaced short palindromic repeat (CRISPR) elements are a particular family of tandem repeats present in prokaryotic genomes, in almost all archaea and in about half of bacteria, and which participate in a mechanism of acquired resistance against phages. They consist in a succession of direct repeats (DR) of 24–47 bp separated by similar sized unique sequences (spacers). In the large majority of cases, the direct repeats are highly conserved, while the number and nature of the spacers are often quite diverse, even among strains of a same species. Furthermore, the acquisition of new units (DR + spacer) was shown to happen almost exclusively on one side of the locus. Therefore, the CRISPR presents an interesting genetic marker for comparative and evolutionary analysis of closely related bacterial strains. CRISPRcompar is a web service created to assist biologists in the CRISPR typing process. Two tools facilitates the in silico investigation: CRISPRcomparison and CRISPRtionary. This website is freely accessible at http://crispr.u-psud.fr/CRISPRcompar/.


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