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Nucleic Acids Research Advance Access published online on August 12, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn520
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Gene Regulation, Chromatin and Epigenetics

The orphan receptor ERR{alpha} interferes with steroid signaling

Catherine Teyssier, Stéphanie Bianco, Olivia Lanvin and Jean-Marc Vanacker*

Institut de Génomique Fonctionnelle de Lyon, Université de Lyon; Institut Fédératif Biosciences Gerland Lyon Sud and Université Lyon 1, CNRS, INRA, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon cedex 07, France

*To whom correspondence should be addressed: Tel: +33 (0) 4 72 72 85 91; Fax: +33 (0) 4 72 72 80 80; Email: Jean-Marc.Vanacker{at}ens-lyon.fr

Received December 4, 2007. Revised July 30, 2008. Accepted July 30, 2008.

The estrogen receptor-related receptor {alpha} (ERR{alpha}) is an orphan member of the nuclear receptor superfamily that has been shown to interfere with the estrogen-signaling pathway. In this report, we demonstrate that ERR{alpha} also cross-talks with signaling driven by other steroid hormones. Treatment of human prostatic cells with a specific ERR{alpha} inverse agonist reduces the expression of several androgen-responsive genes, in a manner that does not involve perturbation of androgen receptor expression or activity. Furthermore, ERR{alpha} activates the expression of androgen response elements (ARE)-containing promoters, such as that of the prostate cancer marker PSA, in an ARE-dependent manner. In addition, promoters containing a steroid response element can be activated by all members of the ERR orphan receptor subfamily, and this, even in the presence of antisteroid compounds.

Present addresses: Catherine Teyssier, Inserm U554, Centre de Biochimie Structurale, Montpellier, France Olivia Lanvin, Inserm U563, Centre Claudius Régaud, Toulouse, France


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