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Nucleic Acids Research Advance Access published online on October 4, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn655
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

PhytAMP: a database dedicated to antimicrobial plant peptides

Riadh Hammami1,2,3, Jeannette Ben Hamida1, Gérard Vergoten2 and Ismail Fliss3,*

1Unité de Protéomie Fonctionnelle & Biopréservation Alimentaire, Institut Supérieur des Sciences Biologiques Appliquées de Tunis, Université El Manar, Tunis, Tunisie 2UMR CNRS 8576 ‘Glycobiologie Structurale et Fonctionnelle’, Université des Sciences et Technologie de Lille, Lille, France and 3Institut des Nutraceutiques et des Aliments Fonctionnels (INAF), Université Laval, Québec, Canada

*To whom correspondence should be addressed. Tel: +1 418 656 2131 (ext. 6825); Fax: +1 418 656 3353; Email: Ismail.Fliss{at}fsaa.ulaval.ca

Received June 20, 2008. Accepted September 18, 2008.

Plants produce small cysteine-rich antimicrobial peptides as an innate defense against pathogens. Based on amino acid sequence homology, these peptides were classified mostly as {alpha}-defensins, thionins, lipid transfer proteins, cyclotides, snakins and hevein-like. Although many antimicrobial plant peptides are now well characterized, much information is still missing or is unavailable to potential users. The compilation of such information in one centralized resource, such as a database would therefore facilitate the study of the potential these peptide structures represent, for example, as alternatives in response to increasing antibiotic resistance or for increasing plant resistance to pathogens by genetic engineering. To achieve this goal, we developed a new database, PhytAMP, which contains valuable information on antimicrobial plant peptides, including taxonomic, microbiological and physicochemical data. Information is very easy to extract from this database and allows rapid prediction of structure/function relationships and target organisms and hence better exploitation of plant peptide biological activities in both the pharmaceutical and agricultural sectors. PhytAMP may be accessed free of charge at http://phytamp.pfba-lab.org.


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