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Nucleic Acids Research Advance Access published online on October 14, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn658
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The assembly of a spliceosomal small nuclear ribonucleoprotein particle

Snehal Bhikhu Patel1 and Michel Bellini2,*

1Biochemistry and College of Medicine and 2Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

*To whom correspondence should be addressed. Tel: +1 217 265 5297; Fax: +1 217 244 6418; Email: bellini{at}life.uiuc.edu

Received July 1, 2008. Revised September 12, 2008. Accepted September 21, 2008.

The U1, U2, U4, U5 and U6 small nuclear ribonucleoprotein particles (snRNPs) are essential elements of the spliceosome, the enzyme that catalyzes the excision of introns and the ligation of exons to form a mature mRNA. Since their discovery over a quarter century ago, the structure, assembly and function of spliceosomal snRNPs have been extensively studied. Accordingly, the functions of splicing snRNPs and the role of various nuclear organelles, such as Cajal bodies (CBs), in their nuclear maturation phase have already been excellently reviewed elsewhere. The aim of this review is, then, to briefly outline the structure of snRNPs and to synthesize new and exciting developments in the snRNP biogenesis pathways.


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