Nucleic Acids Research Advance Access published online on October 4, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn664
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The Universal Protein Resource (UniProt) 2009
1The EMBL Outstation, The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 2Protein Information Resource, Georgetown University Medical Center, 3300 Whitehaven St NW, Suite 1200, Washington, DC 20007, USA and 3Swiss Institute of Bioinformatics, Centre Medical Universitaire 1 rue Michel Servet, 1211 Geneva 4, Switzerland
*To whom correspondence should be addressed. Tel: +44 1223 494435; Fax: +44 1223 494468; Email: apweiler{at}ebi.ac.uk
Received September 15, 2008. Accepted September 19, 2008.
The mission of UniProt is to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information that is essential for modern biological research. UniProt is produced by the UniProt Consortium which consists of groups from the European Bioinformatics Institute, the Protein Information Resource and the Swiss Institute of Bioinformatics. The core activities include manual curation of protein sequences assisted by computational analysis, sequence archiving, a user-friendly UniProt website and the provision of additional value-added information through cross-references to other databases. UniProt is comprised of four major components, each optimized for different uses: the UniProt Archive, the UniProt Knowledgebase, the UniProt Reference Clusters and the UniProt Metagenomic and Environmental Sequence Database. One of the key achievements of the UniProt consortium in 2008 is the completion of the first draft of the complete human proteome in UniProtKB/Swiss-Prot. This manually annotated representation of all currently known human protein-coding genes was made available in UniProt release 14.0 with 20 325 entries. UniProt is updated and distributed every three weeks and can be accessed online for searches or downloaded at www.uniprot.org.
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