Skip Navigation



Nucleic Acids Research Advance Access published online on October 22, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn702
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (9152K) Freely available
Right arrow Screen PDF (1113K) Freely available
Right arrowOA All Versions of this Article:
37/suppl_1/D41    most recent
gkn702v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Taccioli, C.
Right arrow Articles by Croce, C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taccioli, C.
Right arrow Articles by Croce, C. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

UCbase & miRfunc: a database of ultraconserved sequences and microRNA function

Cristian Taccioli1, Enrica Fabbri2, Rosa Visone1, Stefano Volinia1, George A. Calin3, Louise Y. Fong1, Roberto Gambari2, Arianna Bottoni1, Mario Acunzo4, John Hagan1, Marilena V. Iorio5, Claudia Piovan5, Giulia Romano4 and Carlo Maria Croce1,*

1Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA, 2Biochemistry and Molecular Biology Department, University of Ferrara, 44100 Ferrara, Italy, 3Department of Experimental Therapeutics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA, 4Molecular Pathology and Biology Department ‘L.Califano’, ‘Federico II’ Naples University, 80100 Naples and 5IRCCS Foundation, National Tumor Institute, 20100 Milan, Italy

*To whom correspondence should be addressed. Tel: +1 614 292 3063; Fax: +1 614 292 3558; Email: carlo.croce{at}osumc.edu

Received July 9, 2008. Revised September 3, 2008. Accepted September 29, 2008.

Four hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species. UCRs are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs (miRNAs). Here we present UCbase & miRfunc, the first database which provides ultraconserved sequences data and shows miRNA function.

Also, it links UCRs and miRNAs with the related human disorders and genomic properties. The current release contains over 2000 sequences from three species (human, mouse and rat). As a web application, UCbase & miRfunc is platform independent and it is accessible at http://microrna.osu.edu/.UCbase4


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
J. Wang, M. Lu, C. Qiu, and Q. Cui
TransmiR: a transcription factor-microRNA regulation database
Nucleic Acids Res., September 28, 2009; (2009) gkp803v1.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. Y. Galperin and G. R. Cochrane
Nucleic Acids Research annual Database Issue and the NAR online Molecular Biology Database Collection in 2009
Nucleic Acids Res., January 1, 2009; 37(suppl_1): D1 - D4.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.