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Nucleic Acids Research Advance Access published online on November 4, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn854
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

BloodExpress: a database of gene expression in mouse haematopoiesis

Diego Miranda-Saavedra1, Subhajyoti De2, Matthew W. Trotter3, Sarah A. Teichmann2 and Berthold Göttgens1,*

1Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, 2MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH and 3Department of Surgery and Laboratory for Regenerative Medicine, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0SZ, UK

*To whom correspondence should be addressed. Tel: +44 1223 336829; Fax: +44 1223 762670; Email: bg200{at}cam.ac.uk

Received August 26, 2008. Revised October 3, 2008. Accepted October 16, 2008.

Haematopoiesis is the process whereby blood stem cells give rise to at least fourteen functionally distinct mature cell types, and represents the best characterized mammalian adult stem cell system. Here we introduce the BloodExpress database, the first public resource integrating mouse blood cell expression profiles. BloodExpress enables the searching of data from individual studies in a single database accessible through a user-friendly web interface. Microarray datasets have been processed uniformly to allow their comparison on the BloodExpress platform. BloodExpress covers the majority of murine blood cell types, including both progenitors and terminally differentiated cells. This allows for the identification of dynamic changes in gene expression as cells differentiate down the well-defined haematopoietic hierarchy. A gene-centric interface returns haematopoietic expression patterns together with functional annotation and a list of other genes with similar expression patterns. A cell type-centric interface allows the identification of genes expressed at specific points of blood development, with the additional and useful capability of filtering by specific gene functional categories. BloodExpress thus constitutes a platform for the discovery of novel gene functions across the haematopoietic tree. BloodExpress is freely accessible at http://hscl.cimr.cam.ac.uk/bloodexpress/.


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