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Nucleic Acids Research Advance Access published online on November 9, 2008
Nucleic Acids Research, doi:10.1093/nar/gkn881
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

Influenza sequence and epitope database

Seok Yang1,2, Joo-Yeon Lee2, Joon Seung Lee1, Wayne P. Mitchell3,4, Hee-Bok Oh2, Chun Kang2 and Kyung Hyun Kim1,*

1Department of Biotechnology & Bioinformatics, College of Science & Technology, Korea University, Chungnam, 2Center for Infectious Diseases, National Institute of Health, Seoul, Korea, 3Experimental Therapeutics Center, 31 Biopolis Street and 4Division of Information Systems, School of Computer Engineering, Nanyang Technological University, Singapore

* To whom correspondence should be addressed. Tel: +82 2 3290 3444; Fax: +82 2 3290 3945; Email: khkim{at}korea.ac.kr Correspondence may also be addressed to Chun Kang. Tel: 82-2-380-1501; Fax: 82-2-389-2014; Email: ckang{at}nih.go.kr

Received August 15, 2008. Accepted October 17, 2008.

Influenza epidemics arise through the acquisition of viral genetic changes to overcome immunity from previous infections. An increasing number of complete genomes of influenza viruses have been sequenced in Asia in recent years. Knowledge about the genomes of the seasonal influenza viruses from different countries in Asia is valuable for monitoring and understanding of the emergence, migration and evolution of strains. In order to make full use of the wealth of information from such data, we have developed an integrated user friendly relational database, Influenza Sequence and Epitope Database (ISED), that catalogs the influenza sequence and epitope information obtained in Asia. ISED currently hosts a total of 13 020 influenza A and 2984 influenza B virus sequence data collected in 17 countries including 9 Asian countries, and a total of approximately 545 amantadine-resistant influenza virus sequences collected in Korea. ISED provides users with prebuilt application tools to analyze sequence alignment and different patterns and allows users to visualize epitope-matching structures, which is freely accessible at http://influenza.korea.ac.kr.


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