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Nucleic Acids Research Advance Access published online on November 12, 2009
Nucleic Acids Research, doi:10.1093/nar/gkp1038
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© The Author(s) 2009. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

GenomeRNAi: a database for cell-based RNAi phenotypes. 2009 update

Moritz Gilsdorf, Thomas Horn, Zeynep Arziman, Oliver Pelz, Evgeny Kiner and Michael Boutros*

German Cancer Research Center and University of Heidelberg, Division Signaling and Functional Genomics, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany

*To whom correspondence should be addressed. Tel: +49 6221 421951; Fax: +49 6221 421959; Email: m.boutros{at}dkfz.de

Received August 15, 2009. Revised October 15, 2009. Accepted October 16, 2009.

The GenomeRNAi database (http://www.genomernai.org/) contains phenotypes from published cell-based RNA interference (RNAi) screens in Drosophila and Homo sapiens. The database connects observed phenotypes with annotations of targeted genes and information about the RNAi reagent used for the perturbation experiment. The availability of phenotypes from Drosophila and human screens also allows for phenotype searches across species. Besides reporting quantitative data from genome-scale screens, the new release of GenomeRNAi also enables reporting of data from microscopy experiments and curated phenotypes from published screens. In addition, the database provides an updated resource of RNAi reagents and their predicted quality that are available for the Drosophila and the human genome. The new version also facilitates the integration with other genomic data sets and contains expression profiling (RNA-Seq) data for several cell lines commonly used in RNAi experiments.

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.

Present address: Evgeny Kiner, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA02142, USA.


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