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Nucleic Acids Research Advance Access published online on May 13, 2009
Nucleic Acids Research, doi:10.1093/nar/gkp372
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© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Molecular Biology

Histone H2a mRNA interacts with Lin28 and contains a Lin28-dependent posttranscriptional regulatory element

Bingsen Xu1,2 and Yingqun Huang1,*

1Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA and 2Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325000, P.R. China

*To whom correspondence should be addressed. Tel: +1 203 737 2578; Fax: +1 203 785 7134; Email: yingqun.huang{at}yale.edu

Received March 2, 2009. Revised April 21, 2009. Accepted April 24, 2009.

Lin28 has been shown to block the processing of let-7 microRNAs implicated in the regulation of cell growth and differentiation. Here, we show that Lin28 also specifically associates with ribonucleoprotein particles containing the replication-dependent histone H2a mRNA in mouse embryonic stem cells. We further show that the coding region of H2a mRNA harbors high affinity binding sequences for Lin28 and that these sequences stimulate the expression of reporter genes in a Lin28-dependent manner. We suggest that a key function of Lin28 in the maintenance of pluripotency is to promote the expression of the H2a gene (and perhaps also other replication-dependent histone genes) at the posttranscriptional level in order to coordinate histone production with the unique proliferative properties of embryonic stem cells.


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Nucleic Acids Res., December 4, 2009; (2009) gkp1071v1.
[Abstract] [Full Text] [PDF]


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