Skip Navigation



Nucleic Acids Research Advance Access published online on May 13, 2009
Nucleic Acids Research, doi:10.1093/nar/gkp372
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (8181K) Freely available
Right arrow Screen PDF (500K) Freely available
Right arrow Supplementary Data
Right arrowOA All Versions of this Article:
37/13/4256    most recent
gkp372v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Xu, B.
Right arrow Articles by Huang, Y.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xu, B.
Right arrow Articles by Huang, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Molecular Biology

Histone H2a mRNA interacts with Lin28 and contains a Lin28-dependent posttranscriptional regulatory element

Bingsen Xu1,2 and Yingqun Huang1,*

1Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA and 2Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325000, P.R. China

*To whom correspondence should be addressed. Tel: +1 203 737 2578; Fax: +1 203 785 7134; Email: yingqun.huang{at}yale.edu

Received March 2, 2009. Revised April 21, 2009. Accepted April 24, 2009.

Lin28 has been shown to block the processing of let-7 microRNAs implicated in the regulation of cell growth and differentiation. Here, we show that Lin28 also specifically associates with ribonucleoprotein particles containing the replication-dependent histone H2a mRNA in mouse embryonic stem cells. We further show that the coding region of H2a mRNA harbors high affinity binding sequences for Lin28 and that these sequences stimulate the expression of reporter genes in a Lin28-dependent manner. We suggest that a key function of Lin28 in the maintenance of pluripotency is to promote the expression of the H2a gene (and perhaps also other replication-dependent histone genes) at the posttranscriptional level in order to coordinate histone production with the unique proliferative properties of embryonic stem cells.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.