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Nucleic Acids Research Advance Access published online on September 25, 2009
Nucleic Acids Research, doi:10.1093/nar/gkp784
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© The Author(s) 2009. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

MiCroKit 3.0: an integrated database of midbody, centrosome and kinetochore

Jian Ren1,2, Zexian Liu1,2, Xinjiao Gao1, Changjiang Jin1, Mingliang Ye3, Hanfa Zou3, Longping Wen1, Zhaolei Zhang4, Yu Xue1,2,* and Xuebiao Yao1,*

1Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science & Technology of China, Hefei 230027, 2 Department of Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, 3National Chromatographic R&A Center, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China and 4Banting and Best Department of Medical Research and Department of Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada M5S 3E1

*To whom correspondence should be addressed. Tel/Fax: +86 551 3606304; Email: xueyu{at}mail.hust.edu.cn Correspondence may also be addressed to Xuebiao Yao. Tel: +86 551 3606304; Fax: +86 551 3607141; E-mail: yaoxb{at}ustc.edu.cn

Received July 24, 2009. Revised September 4, 2009. Accepted September 4, 2009.

During cell division/mitosis, a specific subset of proteins is spatially and temporally assembled into protein super complexes in three distinct regions, i.e. centrosome/spindle pole, kinetochore/centromere and midbody/cleavage furrow/phragmoplast/bud neck, and modulates cell division process faithfully. Although many experimental efforts have been carried out to investigate the characteristics of these proteins, no integrated database was available. Here, we present the MiCroKit database (http://microkit.biocuckoo.org) of proteins that localize in midbody, centrosome and/or kinetochore. We collected into the MiCroKit database experimentally verified microkit proteins from the scientific literature that have unambiguous supportive evidence for subcellular localization under fluorescent microscope. The current version of MiCroKit 3.0 provides detailed information for 1489 microkit proteins from seven model organisms, including Saccharomyces cerevisiae, Schizasaccharomyces pombe, Caenorhabditis elegans, Drosophila melanogaster, Xenopus laevis, Mus musculus and Homo sapiens. Moreover, the orthologous information was provided for these microkit proteins, and could be a useful resource for further experimental identification. The online service of MiCroKit database was implemented in PHP + MySQL + JavaScript, while the local packages were developed in JAVA 1.5 (J2SE 5.0).


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