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Nucleic Acids Research Advance Access published online on September 26, 2009
Nucleic Acids Research, doi:10.1093/nar/gkp799
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© The Author(s) 2009. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

EMMA—mouse mutant resources for the international scientific community

Phil Wilkinson1, Jitka Sengerova1, Raffaele Matteoni2, Chao-Kung Chen1, Gaetan Soulat3, Abel Ureta-Vidal1, Sabine Fessele4, Michael Hagn4, Marzia Massimi2, Karen Pickford5, Richard H. Butler2, Susan Marschall4, Ann-Marie Mallon5, Amanda Pickard5, Marcello Raspa2, Ferdinando Scavizzi2, Martin Fray5, Vanessa Larrigaldie3, Johan Leyritz3, Ewan Birney1, Glauco P. Tocchini-Valentini2, Steve Brown5, Yann Herault3, Lluis Montoliu6, Martin Hrabé de Angelis4 and Damian Smedley1,*

1European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, 2Consiglio Nazionale delle Ricerche, Istituto di Biologia Cellulare, I-00015, Monterotondo, Italy, 3CNRS-Centre de Cryopréservation, Distribution, Typage et Archivage animal, 45071 Orléans, France, 4Helmholtz Zentrum München, GmbH, Ingolstädter Landstraße 1, D-85764, Neuherberg, Germany, 5MRC – Mammalian Genetics Unit, Harwell, Didcot, OX11 0RD, UK and 6Centro Nacional de Biotecnologia (CNB-CSIC), 28049 Madrid, Spain

*To whom correspondence should be addressed. Tel: 44-1223-494451; Fax: 44-1223-494468; Email: damian{at}ebi.ac.uk

Received August 12, 2009. Revised September 8, 2009. Accepted September 10, 2009.

The laboratory mouse is the premier animal model for studying human disease and thousands of mutants have been identified or produced, most recently through gene-specific mutagenesis approaches. High throughput strategies by the International Knockout Mouse Consortium (IKMC) are producing mutants for all protein coding genes. Generating a knock-out line involves huge monetary and time costs so capture of both the data describing each mutant alongside archiving of the line for distribution to future researchers is critical. The European Mouse Mutant Archive (EMMA) is a leading international network infrastructure for archiving and worldwide provision of mouse mutant strains. It operates in collaboration with the other members of the Federation of International Mouse Resources (FIMRe), EMMA being the European component. Additionally EMMA is one of four repositories involved in the IKMC, and therefore the current figure of 1700 archived lines will rise markedly. The EMMA database gathers and curates extensive data on each line and presents it through a user-friendly website. A BioMart interface allows advanced searching including integrated querying with other resources e.g. Ensembl. Other resources are able to display EMMA data by accessing our Distributed Annotation System server. EMMA database access is publicly available at http://www.emmanet.org.


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