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Nucleic Acids Research Advance Access published online on October 22, 2009
Nucleic Acids Research, doi:10.1093/nar/gkp878
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© The Author(s) 2009. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

The IntAct molecular interaction database in 2010

B. Aranda1, P. Achuthan1, Y. Alam-Faruque1, I. Armean, A. Bridge2, C. Derow1, M. Feuermann2, A. T. Ghanbarian1, S. Kerrien1, J. Khadake1, J. Kerssemakers1, C. Leroy1, M. Menden1, M. Michaut1, L. Montecchi-Palazzi1, S. N. Neuhauser1, S. Orchard1, V. Perreau3, B. Roechert2, K. van Eijk1 and H. Hermjakob1,*

1EMBL Outstation, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus Hinxton, Cambridge, CB10 1SD, UK, 2Swiss Institute of Bioinformatics Geneva, Switzerland and 3Centre for Neuroscience, University of Melbourne, Australia

*To whom correspondence should be addressed. Tel: +44 1223 49 4671; Fax: +44 1223 49 4468; Email: hhe{at}ebi.ac.uk

Received September 11, 2009. Revised October 1, 2009. Accepted October 2, 2009.

IntAct is an open-source, open data molecular interaction database and toolkit. Data is abstracted from the literature or from direct data depositions by expert curators following a deep annotation model providing a high level of detail. As of September 2009, IntAct contains over 200.000 curated binary interaction evidences. In response to the growing data volume and user requests, IntAct now provides a two-tiered view of the interaction data. The search interface allows the user to iteratively develop complex queries, exploiting the detailed annotation with hierarchical controlled vocabularies. Results are provided at any stage in a simplified, tabular view. Specialized views then allows ‘zooming in’ on the full annotation of interactions, interactors and their properties. IntAct source code and data are freely available at http://www.ebi.ac.uk/intact.


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