Nucleic Acids Research Advance Access published online on October 30, 2009
Nucleic Acids Research, doi:10.1093/nar/gkp892
Database Issue |
NNDB: the nearest neighbor parameter database for predicting stability of nucleic acid secondary structure
1Department of Chemistry and Center for RNA Biology, Box 0216, University of Rochester, Rochester, NY 14627-0216 and 2Department of Biochemistry and Biophysics and Center for RNA Biology, Box 712, University of Rochester Medical Center, Rochester, NY 14642, USA
*To whom correspondence should be addressed. Tel: +1 585 275 1734; Fax: +1 585 275 6007; Email: david_mathews{at}urmc.rochester.edu
Received August 17, 2009. Revised October 4, 2009. Accepted October 6, 2009.
The Nearest Neighbor Database (NNDB, http://rna.urmc.rochester.edu/NNDB) is a web-based resource for disseminating parameter sets for predicting nucleic acid secondary structure stabilities. For each set of parameters, the database includes the set of rules with descriptive text, sequence-dependent parameters in plain text and html, literature references to experiments and usage tutorials. The initial release covers parameters for predicting RNA folding free energy and enthalpy changes.