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Nucleic Acids Research Advance Access published online on October 30, 2009

Nucleic Acids Research, doi:10.1093/nar/gkp892
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© The Author(s) 2009. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Database Issue

NNDB: the nearest neighbor parameter database for predicting stability of nucleic acid secondary structure

Douglas H. Turner1 and David H. Mathews2,*

1Department of Chemistry and Center for RNA Biology, Box 0216, University of Rochester, Rochester, NY 14627-0216 and 2Department of Biochemistry and Biophysics and Center for RNA Biology, Box 712, University of Rochester Medical Center, Rochester, NY 14642, USA

*To whom correspondence should be addressed. Tel: +1 585 275 1734; Fax: +1 585 275 6007; Email: david_mathews{at}urmc.rochester.edu

Received August 17, 2009. Revised October 4, 2009. Accepted October 6, 2009.

The Nearest Neighbor Database (NNDB, http://rna.urmc.rochester.edu/NNDB) is a web-based resource for disseminating parameter sets for predicting nucleic acid secondary structure stabilities. For each set of parameters, the database includes the set of rules with descriptive text, sequence-dependent parameters in plain text and html, literature references to experiments and usage tutorials. The initial release covers parameters for predicting RNA folding free energy and enthalpy changes.


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