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Nucleic Acids Research Advance Access published online on November 1, 2009
Nucleic Acids Research, doi:10.1093/nar/gkp914
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© The Author(s) 2009. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

CORUM: the comprehensive resource of mammalian protein complexes—2009

Andreas Ruepp1,*, Brigitte Waegele1,2, Martin Lechner1, Barbara Brauner1, Irmtraud Dunger-Kaltenbach1, Gisela Fobo1, Goar Frishman1, Corinna Montrone1 and H.-Werner Mewes1,2

1Institute for Bioinformatics and Systems Biology (IBIS), Helmholtz Zentrum München—German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, D-85764 Neuherberg and 2Technische Universität München, Chair of Genome Oriented Bioinformatics, Center of Life and Food Science, D-85350 Freising-Weihenstephan, Germany

*To whom correspondence should be addressed. Tel: +49 3187 3189; Fax: +49 3187 3585; Email: andreas.ruepp{at}helmholtz-muenchen.de

Received September 10, 2009. Accepted October 7, 2009.

CORUM is a database that provides a manually curated repository of experimentally characterized protein complexes from mammalian organisms, mainly human (64%), mouse (16%) and rat (12%). Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. The new CORUM 2.0 release encompasses 2837 protein complexes offering the largest and most comprehensive publicly available dataset of mammalian protein complexes. The CORUM dataset is built from 3198 different genes, representing ~16% of the protein coding genes in humans. Each protein complex is described by a protein complex name, subunit composition, function as well as the literature reference that characterizes the respective protein complex. Recent developments include mapping of functional annotation to Gene Ontology terms as well as cross-references to Entrez Gene identifiers. In addition, a ‘Phylogenetic Conservation’ analysis tool was implemented that analyses the potential occurrence of orthologous protein complex subunits in mammals and other selected groups of organisms. This allows one to predict the occurrence of protein complexes in different phylogenetic groups. CORUM is freely accessible at (http://mips.helmholtz-muenchen.de/genre/proj/corum/index.html).


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