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Nucleic Acids Research Advance Access published online on November 12, 2009
Nucleic Acids Research, doi:10.1093/nar/gkp952
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© The Author(s) 2009. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

WormBase: a comprehensive resource for nematode research

Todd W. Harris1,*, Igor Antoshechkin2, Tamberlyn Bieri3, Darin Blasiar3, Juancarlos Chan2, Wen J. Chen2, Norie De La Cruz1, Paul Davis4, Margaret Duesbury4, Ruihua Fang2, Jolene Fernandes2, Michael Han4, Ranjana Kishore2, Raymond Lee2, Hans-Michael Müller2, Cecilia Nakamura2, Philip Ozersky3, Andrei Petcherski2, Arun Rangarajan2, Anthony Rogers4, Gary Schindelman2, Erich M. Schwarz2, Mary Ann Tuli2, Kimberly Van Auken2, Daniel Wang2, Xiaodong Wang2, Gary Williams4, Karen Yook2, Richard Durbin4, Lincoln D. Stein1, John Spieth3 and Paul W. Sternberg2,5

1Ontario Institute For Cancer Research, Toronto, ON, Canada M5G0A3, 2California Institute of Technology, Division of Biology 156-29, Pasadena, CA 91125, 3Genome Sequencing Center, Washington University School of Medicine, St Louis, MO 63108, USA, 4Sanger Institute, Wellcome Trust Genome Campus Hinxton, Cambridgeshire CB10 1SA, UK and 5Howard Hughes Medical Institute, California Institute of Technology Pasadena, CA 91125, USA

*To whom correspondence should be addressed. Tel: +1 406 222 2450; Email: info{at}toddharris.net

Received September 15, 2009. Revised October 11, 2009. Accepted October 12, 2009.

WormBase (http://www.wormbase.org) is a central data repository for nematode biology. Initially created as a service to the Caenorhabditis elegans research field, WormBase has evolved into a powerful research tool in its own right. In the past 2 years, we expanded WormBase to include the complete genomic sequence, gene predictions and orthology assignments from a range of related nematodes. This comparative data enrich the C. elegans data with improved gene predictions and a better understanding of gene function. In turn, they bring the wealth of experimental knowledge of C. elegans to other systems of medical and agricultural importance. Here, we describe new species and data types now available at WormBase. In addition, we detail enhancements to our curatorial pipeline and website infrastructure to accommodate new genomes and an extensive user base.


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