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Nucleic Acids Research Advance Access published online on November 11, 2009
Nucleic Acids Research, doi:10.1093/nar/gkp998
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© The Author(s) 2009. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Database Issue

Improvements to services at the European Nucleotide Archive

Rasko Leinonen1,*, Ruth Akhtar1, Ewan Birney1, James Bonfield2, Lawrence Bower1, Matt Corbett1, Ying Cheng1, Fehmi Demiralp1, Nadeem Faruque1, Neil Goodgame1, Richard Gibson1, Gemma Hoad1, Christopher Hunter1, Mikyung Jang1, Steven Leonard2, Quan Lin1, Rodrigo Lopez1, Michael Maguire1, Hamish McWilliam1, Sheila Plaister1, Rajesh Radhakrishnan1, Siamak Sobhany1, Guy Slater2, Petra Ten Hoopen1, Franck Valentin1, Robert Vaughan1, Vadim Zalunin1, Daniel Zerbino1 and Guy Cochrane1

1European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD and 2Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK

*To whom correspondence should be addressed. Tel: +44 1223 494608; Fax: +44 1223 494468; Email: rasko{at}ebi.ac.uk

Received October 15, 2009. Accepted October 16, 2009.

The European Nucleotide Archive (ENA; http://www.ebi.ac.uk/ena) is Europe’s primary nucleotide sequence archival resource, safeguarding open nucleotide data access, engaging in worldwide collaborative data exchange and integrating with the scientific publication process. ENA has made significant contributions to the collaborative nucleotide archival arena as an active proponent of extending the traditional collaboration to cover capillary and next-generation sequencing information. We have continued to co-develop data and metadata representation formats with our collaborators for both data exchange and public data dissemination. In addition to the DDBJ/EMBL/GenBank feature table format, we share metadata formats for capillary and next-generation sequencing traces and are using and contributing to the NCBI SRA Toolkit for the long-term storage of the next-generation sequence traces. During the course of 2009, ENA has significantly improved sequence submission, search and access functionalities provided at EMBL–EBI. In this article, we briefly describe the content and scope of our archive and introduce major improvements to our services.


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