Nucleic Acids Research, 2003, Vol. 31, No. 1 1-12
© 2003 Oxford University Press
The Molecular Biology Database Collection: 2003 update
Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Building 50, Room 5222, Bethesda, MD 20892-8002, USA
*To whom correspondence should be addressed. Tel: +1 3014968570; Fax: +1 3014802634; Email: andy{at}nhgri.nih.gov
Received October 31, 2002; Revised and Accepted November 8, 2002
ABSTRACT
The Molecular Biology Database Collection is an online resource listing key databases of value to the biological community. This Collection is intended to bring fellow scientists' attention to high-quality databases that are available throughout the world, rather than just be a lengthy listing of all available databases. As such, this up-to-date listing is intended to serve as the jumping-off point from which to find specialized databases that may be of use in advancing biological research. The databases included in this Collection provide new value to the underlying data by virtue of curation, new data connections or other innovative approaches. Short, searchable summaries and updates for each of the databases included in this Collection are available through the Nucleic Acids Research Web site at http://nar.oupjournals.org.
COMMENTARY
The biological community will mark the completion of the Human Genome Project's major goal in April 2003: complete, high-accuracy sequencing of the human genome (1). This remarkable achievement, often compared to landing a man on the moon, lays the groundwork for a fundamental shift in how biological and biomedical research will be performed in the future. The free, widespread availability of a wide variety of data beyond human genome sequence—sequence variation data, model organism sequence data, expression data and proteomic data, to name a few—will provide a fertile playground for biologists in all disciplines to better-design and interpret their laboratory and clinical experiments, hopefully accelerating the pace of biological discovery.
Even though human sequencing is not yet ‘complete’ as a whole, sequencing has been completed on six human chromosomes as of the time of this writing (6, 7, 20, 21, 22 and Y). Along with the data available from numerous completed model genomes, the major public databases contain a phenomenal amount of sequence data. Currently, GenBank contains >17 billion nucleotide bases, representing >14 million sequences in 100 000 species. While the opportunities that this massive data set presents is mind-boggling, it also presents a problem in that the inexperienced user will either not know how to approach the data space or not know how to make best use of the data available to them. This problem will only continue to compound as GenBank continues its exponential rate of growth, with doubling rates on the order of 14 months or less. With the recent announcement of plans to sequence ‘high-priority’ model organisms by the National Human Genome Research Institute (NHGRI), it becomes more and more obvious that all biologists will need to avail themselves of the basic tools with which to navigate this large ‘sequence space’, as well as specialized databases that provide potentially easier access to subsets of the data.
Despite the large amount of publicity surrounding the Human Genome Project, a recent survey conducted on behalf of the Wellcome Trust indicates that only half of biomedical researchers using genome databases are familiar with the tools that can be used to actually access the data. For example, only 11% of those surveyed used the European Bioinformatics Institute's Ensembl Web site regularly, with 24% using it occasionally. Half of the remaining users had never even heard of Ensembl or its Web site. This low level of usage has led the Wellcome Trust to establish an advertising campaign aimed at increasing the public awareness of the availability of free tools such as Ensembl for searching human genome sequence data. Anecdotally, there is a similar lack of awareness or familiarity with the tools available through the University of California, Santa Cruz (UCSC) and, quite surprisingly, the National Center for Biotechnology Information (NCBI) at the National Institutes of Health, even though many biologists visit the NCBI Web site frequently. In response to this low level of awareness of the tools freely available to biologists, Wolfsberg et al. (2), developed a ‘user's guide’ to the human genome, intended to provide an elementary, hands-on guide for browsing and analyzing data produced by the International Human Genome Sequencing Consortium and other systematic sequencing efforts. The guide provides step-by-step instructions and strategies for using many of the most commonly-used tools for sequence-based discovery. NCBI, Ensembl and UCSC are all also in the process of developing (or have already released) similar, online guides for using the tools available on their respective Web sites.
While educational efforts such as this help to address the need for rational ways to approach mining genomic data, additional efforts in the form of providing curated views of the data in specialized databases have been taking place for many years now. These efforts afford tremendous value to the biological researcher since they, in essence, reduce the massive ‘sequence space’ to specific, tractable areas of inquiry and, by doing so, allow for the inclusion of many more types of data than are found in the larger data repositories. These databases often provide not just sequence-based information, but additional data such as gene expression, macromolecular interactions, or biological pathway information, data that might not fit neatly onto a large physical map of a genome. Most importantly, data in these smaller, specialized databases tends to be curated by experts in a particular specialty and are often experimentally-verified, meaning that they represent the best state of knowledge in that particular area. This journal has devoted its first issue over the last several years to documenting the availability and features of these specialized databases in order to better-serve its readership, to promote the use of these resources in the design and analysis of experiments and to encourage the continued development of these resources. These reviewed databases are collectively listed in the Molecular Biology Database Collection.
The databases listed in this Collection distinguish themselves by their approach to presenting the underlying data—by adding new value to the underlying data by virtue of curation, by providing new types of data connections, or by implementing other innovative approaches that facilitate biological discovery. The individual entries are classified by type, but the reader should recognize that the distinctions between these classes are often arbitrary, and that many of these databases provide more than one type of information to the user.
In addition to the list presented in this paper, an electronic version of the Database Issue and Collection can be accessed online and is freely available to everyone, regardless of subscription status, at http://nar.oupjournals.org. While the list contains the databases described in the papers comprising the current issue, it should be immediately apparent to the reader that there are simply not enough pages in this issue to accommodate full-length, printed descriptions of all of the databases making up the Collection. To address this, the online version of the Collection provides short summaries of many of the databases, the summaries having been provided directly by the investigators responsible for the individual databases. Contributors have been asked to point out new features of their databases in the Recent Developments section of their entry. It is hoped that this approach will provide the reader with an additional source of information that will facilitate finding and selecting the sources of data that would be of most value in addressing a specific biological problem. Contributors are encouraged to keep their entries up-to-date.
Suggestions for the inclusion of additional database resources in this Collection are encouraged and may be directed to the author (andy{at}nhgri.nih.gov).
ACKNOWLEDGEMENTS
I wish to thank Ken Trout for maintaining the online submission Web site for the Collection, as well as for his technical support throughout this project. I also wish to thank Debbie Wilson and Karen Otto for providing logistical support and for their assistance in tracking and processing the manuscripts that appear in this issue.
|
REFERENCES
- Collins,F.S., Patrinos,A., Jordan,E., Chakravarti,A., Gestetland,R., Walters,L. and Members of the DOE and NIH Planning Groups (1998) New goals for the US Human Genome Project: 1998–2003. Science, 282, 682–689.
[Abstract/Free Full Text] - Wolfsberg,T.G., Wetterstrand,K.A., Guyer,M.S., Collins,F.S. and Baxevanis,A.D. (2002) A User's Guide to the Human Genome. Nature Genet., 32(suppl.), 1–79.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. Luistro, W. He, M. Smith, K. Packman, M. Vilenchik, D. Carvajal, J. Roberts, J. Cai, W. Berkofsky-Fessler, H. Hilton, et al. Preclinical Profile of a Potent {gamma}-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties Cancer Res., October 1, 2009; 69(19): 7672 - 7680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Duraisingham, J. Hornig, F. Gotch, and S. Patterson TLR-Stimulated CD34 Stem Cell-Derived Human Skin-Like and Monocyte-Derived Dendritic Cells Fail to Induce Th17 Polarization of Naive T Cells but Do Stimulate Th1 and Th17 Memory Responses J. Immunol., August 15, 2009; 183(4): 2242 - 2251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. B. Salvesen, S. L. Carter, M. Mannelqvist, A. Dutt, G. Getz, I. M. Stefansson, M. B. Raeder, M. L. Sos, I. B. Engelsen, J. Trovik, et al. Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation PNAS, March 24, 2009; 106(12): 4834 - 4839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. W. Quinn, N. A. Sims, H. Saleh, D. Mirosa, K. Thompson, S. Bouralexis, E. C. Walker, T. J. Martin, and M. T. Gillespie IL-23 Inhibits Osteoclastogenesis Indirectly through Lymphocytes and Is Required for the Maintenance of Bone Mass in Mice J. Immunol., October 15, 2008; 181(8): 5720 - 5729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Guerra, M. Trerotola, R. Dell' Arciprete, V. Bonasera, B. Palombo, T. El-Sewedy, T. Ciccimarra, C. Crescenzi, F. Lorenzini, C. Rossi, et al. A Bicistronic CYCLIN D1-TROP2 mRNA Chimera Demonstrates a Novel Oncogenic Mechanism in Human Cancer Cancer Res., October 1, 2008; 68(19): 8113 - 8121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Paccione, H. Miyazaki, V. Patel, A. Waseem, J. S. Gutkind, Z. E. Zehner, and W. A. Yeudall Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility Mol. Cancer Ther., September 1, 2008; 7(9): 2894 - 2903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Schachtner, D. Lutter, P. Knollmuller, A. M. Tome, F. J. Theis, G. Schmitz, M. Stetter, P. G. Vilda, and E. W. Lang Knowledge-based gene expression classification via matrix factorization Bioinformatics, August 1, 2008; 24(15): 1688 - 1697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Christianson, S. Nicoloro, J. Straubhaar, and M. P. Czech Stearoyl-CoA Desaturase 2 Is Required for Peroxisome Proliferator-activated Receptor {gamma} Expression and Adipogenesis in Cultured 3T3-L1 Cells J. Biol. Chem., February 1, 2008; 283(5): 2906 - 2916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Murphy, H. J. Legere III, and H. R. Katz Activation of Protein Kinase D1 in Mast Cells in Response to Innate, Adaptive, and Growth Factor Signals J. Immunol., December 1, 2007; 179(11): 7876 - 7882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pindado, J. Balsinde, and M. A. Balboa TLR3-Dependent Induction of Nitric Oxide Synthase in RAW 264.7 Macrophage-Like Cells via a Cytosolic Phospholipase A2/Cyclooxygenase-2 Pathway J. Immunol., October 1, 2007; 179(7): 4821 - 4828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Johnson, A. Esquela-Kerscher, G. Stefani, M. Byrom, K. Kelnar, D. Ovcharenko, M. Wilson, X. Wang, J. Shelton, J. Shingara, et al. The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells Cancer Res., August 15, 2007; 67(16): 7713 - 7722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. Dunkley, J. L. McReynolds, M. E. Hume, C. S. Dunkley, T. R. Callaway, L. F. Kubena, D. J. Nisbet, and S. C. Ricke Molting in Salmonella Enteritidis-Challenged Laying Hens Fed Alfalfa Crumbles. I. Salmonella Enteritidis Colonization and Virulence Gene hilA Response Poult. Sci., August 1, 2007; 86(8): 1633 - 1639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Meng, I. Vera, N. Che, X. Wang, S. S. Wang, L. Ingram-Drake, E. E. Schadt, T. A. Drake, and A. J. Lusis Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics PNAS, March 13, 2007; 104(11): 4530 - 4535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Meng, Y. Zhang, and X.-Q. Liu Rare Group I Intron with Insertion Sequence Element in a Bacterial Ribonucleotide Reductase Gene J. Bacteriol., March 1, 2007; 189(5): 2150 - 2154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Chen, M. McGee, Q. Liu, and R. H. Scheuermann A distribution free summarization method for Affymetrix GeneChip(R) arrays Bioinformatics, February 1, 2007; 23(3): 321 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Banerjee, M. Chatterjee, Y. Yu, S.-G. Suh, W. A. Miller, and D. J. Hannapel Dynamics of a Mobile RNA of Potato Involved in a Long-Distance Signaling Pathway PLANT CELL, December 1, 2006; 18(12): 3443 - 3457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Schrader, C. Young, D. Kozian, R. Hoffmann, and F. Lottspeich Temperature-sensitive eIF5A Mutant Accumulates Transcripts Targeted to the Nonsense-mediated Decay Pathway J. Biol. Chem., November 17, 2006; 281(46): 35336 - 35346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Scicchitano, D. A. Dalmas, M. A. Bertiaux, S. M. Anderson, L. R. Turner, R. A. Thomas, R. Mirable, and R. W. Boyce Preliminary Comparison of Quantity, Quality, and Microarray Performance of RNA Extracted From Formalin-fixed, Paraffin-embedded, and Unfixed Frozen Tissue Samples J. Histochem. Cytochem., November 1, 2006; 54(11): 1229 - 1237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Mattarucchi, M. Marsoni, A. Passi, F. Lo Curto, F. Pasquali, and G. Porta Establishment and Study of Different Real-Time Polymerase Chain Reaction Assays for the Quantification of Cells with Deletions of Chromosome 7 J. Mol. Diagn., May 1, 2006; 8(2): 218 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hochreiter, D.-A. Clevert, and K. Obermayer A new summarization method for affymetrix probe level data Bioinformatics, April 15, 2006; 22(8): 943 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Byfield, H. Xue, and R. G. Upchurch Two Genes from Soybean Encoding Soluble {Delta}9 Stearoyl-ACP Desaturases Crop Sci., February 24, 2006; 46(2): 840 - 846. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. W.-L. Li, J. Li, S. L. Timmerman, L. A. Krushel, and S. L. Martin The dicistronic RNA from the mouse LINE-1 retrotransposon contains an internal ribosome entry site upstream of each ORF: implications for retrotransposition Nucleic Acids Res., February 6, 2006; 34(3): 853 - 864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Tyshenko and W. Leiss Current trends in publicly available genetic databases Health Informatics Journal, December 1, 2005; 11(4): 295 - 308. [Abstract] [PDF]
|
|
|
|
|
|
S. Ullrich, M. Kube, S. Schubbe, R. Reinhardt, and D. Schuler A Hypervariable 130-Kilobase Genomic Region of Magnetospirillum gryphiswaldense Comprises a Magnetosome Island Which Undergoes Frequent Rearrangements during Stationary Growth J. Bacteriol., November 1, 2005; 187(21): 7176 - 7184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Meng, Y. Wang, and X.-Q. Liu An Intron-encoded Protein Assists RNA Splicing of Multiple Similar Introns of Different Bacterial Genes J. Biol. Chem., October 21, 2005; 280(42): 35085 - 35088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Mount and R. Pandey Using bioinformatics and genome analysis for new therapeutic interventions Mol. Cancer Ther., October 1, 2005; 4(10): 1636 - 1643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsunaga and M.-a. Muramatsu Knowledge-based computational search for genes associated with the metabolic syndrome Bioinformatics, July 15, 2005; 21(14): 3146 - 3154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-M. K. Hein, S. Richardson, H. C. Causton, G. K. Ambler, and P. J. Green BGX: a fully Bayesian integrated approach to the analysis of Affymetrix GeneChip data Biostat., July 1, 2005; 6(3): 349 - 373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Forche, G. May, and P. T. Magee Demonstration of Loss of Heterozygosity by Single-Nucleotide Polymorphism Microarray Analysis and Alterations in Strain Morphology in Candida albicans Strains during Infection Eukaryot. Cell, January 1, 2005; 4(1): 156 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Swanson, M. J. Mazur, K. Vashisht, L. A. Rund, J. E. Beever, C. M. Counter, and L. B. Schook Genomics and Clinical Medicine: Rationale for Creating and Effectively Evaluating Animal Models Experimental Biology and Medicine, October 1, 2004; 229(9): 866 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Miller, L. M. Callahan, C. Casaceli, L. Chen, G. L. Kiser, B. Chui, T. M. Kaysser-Kranich, T. J. Sendera, C. Palaniappan, and H. J. Federoff Dysregulation of Gene Expression in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Mouse Substantia Nigra J. Neurosci., August 25, 2004; 24(34): 7445 - 7454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Choudhary, J. A. Sommers, and R. M. Brosh Jr. Biochemical and Kinetic Characterization of the DNA Helicase and Exonuclease Activities of Werner Syndrome Protein J. Biol. Chem., August 13, 2004; 279(33): 34603 - 34613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zipper, H. Brunner, J. Bernhagen, and F. Vitzthum Investigations on DNA intercalation and surface binding by SYBR Green I, its structure determination and methodological implications Nucleic Acids Res., July 12, 2004; 32(12): e103 - e103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bralley and G. H. Jones Organization and Expression of the Polynucleotide Phosphorylase Gene (pnp) of Streptomyces: Processing of pnp Transcripts in Streptomyces antibioticus J. Bacteriol., May 15, 2004; 186(10): 3160 - 3172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lewandowska, C. G. Simpson, G. P. Clark, N. S. Jennings, M. Barciszewska-Pacak, C.-F. Lin, W. Makalowski, J. W.S. Brown, and A. Jarmolowski Determinants of Plant U12-Dependent Intron Splicing Efficiency PLANT CELL, May 1, 2004; 16(5): 1340 - 1352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Fountain, A. Cheong, R. Flemming, L. Mair, A. Sivaprasadarao, and D. J. Beech Functional up-regulation of KCNA gene family expression in murine mesenteric resistance artery smooth muscle J. Physiol., April 1, 2004; 556(1): 29 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Li, X. Zhou, M.A.R. St. John, and D.T.W. Wong RNA Profiling of Cell-free Saliva Using Microarray Technology Journal of Dental Research, March 1, 2004; 83(3): 199 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nakadai, M. Shimada, D. Shima, H. Handa, and T.-a. Tamura Specific Interaction with Transcription Factor IIA and Localization of the Mammalian TATA-binding Protein-like Protein (TLP/TRF2/TLF) J. Biol. Chem., February 27, 2004; 279(9): 7447 - 7455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. de Pereda, W. F. Waas, Y. Jan, E. Ruoslahti, P. Schimmel, and J. Pascual Crystal Structure of a Human Peptidyl-tRNA Hydrolase Reveals a New Fold and Suggests Basis for a Bifunctional Activity J. Biol. Chem., February 27, 2004; 279(9): 8111 - 8115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Reader, D. Metzgar, P. Schimmel, and V. de Crecy-Lagard Identification of Four Genes Necessary for Biosynthesis of the Modified Nucleoside Queuosine J. Biol. Chem., February 20, 2004; 279(8): 6280 - 6285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Y. Rhee Carpe Diem. Retooling the "Publish or Perish" Model into the "Share and Survive" Model Plant Physiology, February 1, 2004; 134(2): 543 - 547. [Full Text] [PDF]
|
|
|
|
|
|
H. Yakhnin, H. Zhang, A. V. Yakhnin, and P. Babitzke The trp RNA-Binding Attenuation Protein of Bacillus subtilis Regulates Translation of the Tryptophan Transport Gene trpP (yhaG) by Blocking Ribosome Binding J. Bacteriol., January 15, 2004; 186(2): 278 - 286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Tulman, C. L. Afonso, Z. Lu, L. Zsak, G. F. Kutish, and D. L. Rock The Genome of Canarypox Virus J. Virol., January 1, 2004; 78(1): 353 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. R. LINGER, L. KUNOVSKA, R. J. KUHN, and B. L. GOLDEN Sindbis virus nucleocapsid assembly: RNA folding promotes capsid protein dimerization RNA, January 1, 2004; 10(1): 128 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Y. Galperin The Molecular Biology Database Collection: 2004 update Nucleic Acids Res., January 1, 2004; 32(90001): D3 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Baines, J. Parsch, and W. Stephan Pleiotropic Effect of Disrupting a Conserved Sequence Involved in a Long-Range Compensatory Interaction in the Drosophila Adh Gene Genetics, January 1, 2004; 166(1): 237 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Kulkarni-Kale, S. Bhosle, G. S. Manjari, and A. S. Kolaskar VirGen: a comprehensive viral genome resource Nucleic Acids Res., January 1, 2004; 32(90001): D289 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wiederkehr, R. Basavaraj, C. Sarrauste de Menthiere, L. Hermida, R. Koch, U. Schlecht, A. Amon, S. Brachat, M. Breitenbach, P. Briza, et al. GermOnline, a cross-species community knowledgebase on germ cell differentiation Nucleic Acids Res., January 1, 2004; 32(90001): D560 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Liang, U. Matrubutham, B. Parvizi, J. Yen, D. Duan, J. Mirchandani, S. Hashima, U. Nguyen, E. Ubil, J. Loewenheim, et al. ORFDB: an information resource linking scientific content to a high-quality Open Reading Frame (ORF) collection Nucleic Acids Res., January 1, 2004; 32(90001): D595 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cieslak, J. Szymanski, R. W. Adamiak, and C. S. Cierniewski Structural Rearrangements of the 10-23 DNAzyme to {beta}3 Integrin Subunit mRNA Induced by Cations and Their Relations to the Catalytic Activity J. Biol. Chem., November 28, 2003; 278(48): 47987 - 47996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-Q. Liu, J. Yang, and Q. Meng Four Inteins and Three Group II Introns Encoded in a Bacterial Ribonucleotide Reductase Gene J. Biol. Chem., November 21, 2003; 278(47): 46826 - 46831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Handa, T. Saha, and K. Usdin The fragile X syndrome repeats form RNA hairpins that do not activate the interferon-inducible protein kinase, PKR, but are cut by Dicer Nucleic Acids Res., November 1, 2003; 31(21): 6243 - 6248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. RAMOS, D. HOLLINGWORTH, and A. PASTORE G-quartet-dependent recognition between the FMRP RGG box and RNA RNA, October 1, 2003; 9(10): 1198 - 1207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. P. van Kuilenburg, R. Meinsma, B. A. Zonnenberg, L. Zoetekouw, F. Baas, K. Matsuda, N. Tamaki, and A. H. van Gennip Dihydropyrimidinase Deficiency and Severe 5-Fluorouracil Toxicity Clin. Cancer Res., October 1, 2003; 9(12): 4363 - 4367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Gubbins, D. C. Arthur, A. F. Ghetu, J. N. M. Glover, and L. S. Frost Characterizing the Structural Features of RNA/RNA Interactions of the F-plasmid FinOP Fertility Inhibition System J. Biol. Chem., July 18, 2003; 278(30): 27663 - 27671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. Vannier and R. M. Summers Sharing Images Radiology, July 1, 2003; 228(1): 23 - 25. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Camon, M. Magrane, D. Barrell, D. Binns, W. Fleischmann, P. Kersey, N. Mulder, T. Oinn, J. Maslen, A. Cox, et al. The Gene Ontology Annotation (GOA) Project: Implementation of GO in SWISS-PROT, TrEMBL, and InterPro Genome Res., April 1, 2003; 13(4): 662 - 672. [Abstract] [Full Text] [PDF]
|
|
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||