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Figure 2 tRNA methylation analyzed by microarray. (A) Three different types of detectable methylation. Unique tRNA probes with ratios of at least 2 are color-coded according to the scale shown and displayed from 5' to 3' of the tRNA sequence. The tRNA isoforms and specific nucleotides covered are shown to the right of the figure. Oligos predicted to be affected in the each experiment are outlined with blue rectangles. (B) Schematic representation of selected tRNAs. One tRNA from each of the experiments in which the methylation defect was detected is shown in schematic form as described in Figure 1A. Functional groups involved in Watson–Crick base pairing are circled in blue; modifications are circled in red.
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