Nucleic Acids Research, 1983, Vol. 11, No. 13 4601-4610
© 1983
MOLECULAR BIOLOGY |
Cloning and structural analyses of hepatitis B virus DNAs, subtype adr
*National Institute of Health Shinagawa-ku, Tokyo 141 +The Chemo-Sero-Therapeutic Research Institute Shimizu, Kumamoto 860, Japan Institute for Molecular and Cellular Biology, Osaka University Kita-ku, Osaka 530
Received April 7, 1983. Revised June 15, 1983. Accepted June 15, 1983.
Entire genomes of hepatitis B virus (subtype adr) have been cloned. The nucleotide sequence data were compared with other sequences of HBV genome including: adw [Valenzuela et al. (1981) in Animal Virus Genetics. Fields et al. eds. Academic Press, Inc., NY. pp. 57–70], ayw [Galibert et al. (1979) Nature, 281, 646–650], and adyw [Pasek et al. (1979) Nature 282, 575–579]. Four open coding frames for polypeptides larger than 6,000 dalton were found to be conserved and were highly compressed by overlapping with each other in one strand (L-strand). Sites of initiation of the S gene and termination of the P gene were not conserved. No conserved coding frame was found on the opposite strand (S strand). Amino acid sequences of six surface antigen (HBsAg) peptides, including subtypes adr, adw, and ayw, are deduced from the DNA sequences, and the substitution of amino acid residues which are consistent with the change of subtypes are demonstrated.
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