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Nucleic Acids Research, 1983, Vol. 11, No. 14 4703-4712
© 1983

MOLECULAR BIOLOGY

Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 hemagglutinin

Martine Verhoeyen, Ludo Van Rompuy, Willy Min Jou, Danny Huylebroeck and Walter Fiers

Laboratory of Molecular Biology, State University of Ghent Ledeganckstraat 35, B-9000 Ghent, Belgium

Received June 3, 1983. Accepted June 27, 1983.

The complete nucleotide sequence of the hemagglutinin (HA) gene of the human type B influenza virus B/Singapore/222/79 1s presented. Comparison with the only other known sequence of a B hemagglutinin (B/Lee/40) shows that antigenic drift in type B HA genes is essentially the same as already observed within the influenza A H3 subtype, i.e., an accumulation of point mutations. The main difference is that the apparent evolution is significantly slower, most likely due to the cumulative effect of a lower occurrence in the population (slower evolution) and/or less immunological pressure. There is a striking cluster of changes at positions 127 until 137 of the HA1 subunit which may represent one of the antigenic sites of the molecule.


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