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Nucleic Acids Research, 1983, Vol. 11, No. 15 5235-5242
© 1983

MOLECULAR BIOLOGY

Different levels of induction of RecA protein in E. coli (PQ 10) after treatment with two related carcinogens

Bernard Salles*, Marie Claude Lang+, Anne Marie Freund+, Claude Paoletti*, Michel Daune+ and Robert P.P. Fuchs+

*Laboratoire de Pharmacologie et Toxicologie Fondamentales 205, route de Narbonne, 31078 Toulouse Cedex +Laboratoire de Biophysique, Institut de Biologie Moleculaire et Cellulaire du CNRS 15 rue Rene Descartes, 67084 Strasbourg Cedex, France

Received June 13, 1983. Accepted July 4, 1983.

By means of an immunoradiotnetric assay the Induction of protein RecA in E. coli PQ 10 was measured after treatment by two related carcinogens. On an adduct basis N-Acetoxy-N-2-acetylaminofluorene was shown to induce the protein RecA at a similar level as U.V. On the other hand, N-hydroxy-N-2-aminofluorene shows only a poor induction capacity of the RecA protein. The difference in the SOS inducing potential of the aminofluorene and acetylami-nofluorene adducts is discussed in relation to the major difference in the local conformational change the two adducts induce in DNA.


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