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Nucleic Acids Research, 1983, Vol. 11, No. 16 5327-5346
© 1983

MOLECULAR BIOLOGY

Mammalian keratin gene families: organisation of genes coding for the B2 high-sulphur proteins of sheep wool

B.C. Powell*, M.J. Sleigh+, K.A. Ward§ and G.E. Rogers*

*Department of Biochemistry, University of Adelaide Adelaide, SA 5000 +CSIRO, Molecular and Cellular Biology Unit North Ryde, NSW 2113 §CSIRO, Division of Animal Production Prospect, NSW 2149, Australia

Received July 8, 1983. Accepted March 1, 1983.

We have Isolated two genomic clones containing three B2 high-sulphur keratin genes from a sheep genomic library constructed 1n Charon 4A. These genes do not contain Intervening sequences. Two genes, encoding the B2A and B20 proteins are closely linked in the genome, being separated by 1.9 kb, and are transcribed 1n the same direction. Although there 1s extensive sequence conservation in the 5' non-coding and coding regions, the 3' non-coding regions diverge both in length and sequence. Within the 5' non-coding region adjacent to the Initiating AUG there is a highly conserved 18 bp sequence which is also present in another gene coding for a member of a different, unrelated high-sulphur keratin family. In the B2A-B2D intergene region, tightly linked to the B2D gene, there is a putative, divergently transcribed gene.


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