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Nucleic Acids Research, 1983, Vol. 11, No. 20 7191-7203
© 1983

MOLECULAR BIOLOGY

Antigenicity and evolution amongst recent influenza viruses of HIN1 subtype

F.Lucy Raymond*, Andrew J. Caton, Nancy J. Cox1, Alan P. Kendal1 and George G. Brownlee

Sir William Dunn School of Pathology, University of Oxford Oxford OX1 3RE, UK 1Center for Infectious Diseases Atlanta, GA 30333, USA

*To whom reprint requests should be sent

Received July 29, 1983. Revised September 28, 1983. Accepted September 28, 1983.

The sequence of the HAl subunit region of the haemagglutinin gene of influenza A/USSR/90/77, and A/Brazil/11/78, A/Lackland/3/78, A/England/333/ 80 and A/India/6263/80 was determined by dideoxy-sequencing methods using total virion RHA and specific oligonucleotide primers for reverse trans criptase. These 1977–1980 strains share a minimum of 85% amino acid sequence homology with influenza A/PR/8/34. Most of the surface amino acid substitutions which occurred during the evolution of A/PR/8/34 to A/USSR/90/77 and subsequently in the 1978–1980 strains are located in the 4 antigenic sites previously defined by an analysis of laboratory-eelected mutants of A/PR/8/34. We deduce an evolutionary pathway for the 1977–80 strains and suggest their different epidemic properties may be a consequence of only a few amino acid changes.


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