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Nucleic Acids Research, 1983, Vol. 11, No. 21 7545-7554
© 1983

CHEMISTRY

Synthesis of ppTppp via phosphotriester intermediates

Cecile Schattenkerk, G.M. Visser, G.A. van der Mard and J.H. van Boom*

Gorlaeus Laboratories P.O.Box 9502, 2300 RA Leiden, The Netherlands

*To whom correspondence should be addressed

Received September 6, 1983. Accepted October 4, 1983.

The bifunctional and crystalline phosphorylating agent roorpholino-0,0-bis[l-benzotriazolyl]phosphate has been used for the preparation of a 3',5'-bis-phosphotriester intermediate of thymidine. The latter has been converted Into ppTppp by the following consecutive steps; removal of the benzotriazolyl group followed by the addition of phosphoric acid and removal of the 2-(4-nitrophenyl)-ethyl group followed by the addition of pyrophosphoric acid.


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