Nucleic Acids Research, 1983, Vol. 11, No. 21 7579-7593
© 1983
CHEMISTRY |
Species-specific homogeneity of the primate Alu family of repeated DNA sequences
1Department of Biochemistry, Louisiana State University 1901 Perdido Street, New Orleans, LA 70112 2Department of Chemistry, University of California Davis, CA 95616, USA
*Present Adrress of M.F.: AMCEN, 1900 Oak Terrance In., Thousand Oaks, CA 91320
Received August 3, 1983. Revised October 5, 1983. Accepted October 5, 1983.
We have determined the base sequence of several cloned Alu family members from the DNAs of a new world monkey (owl monkey) and a prosimian (galago). The three owl monkey Alu family members reported here belong to a single 300 base pair consensus sequence tfiich closely resembles the human Alu family consensus. The galago Alu family members can best be represented as belonging to either of two related but distinct consensus sequences. Che of the two galago Alu family subgroups (Type I) more accurately resembles the human consensus sequence than does the other subgroup (Type II). In this work we compare base sequences of human and galago Type I Alu family members. There are several examples of species-specific differences between the human and Type I galago sequences indicating that the Alu family members are effectively homogenized within a species.