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Nucleic Acids Research, 1983, Vol. 11, No. 22 7819-7831
© 1983

MOLECULAR BIOLOGY

The structure of rat 28S ribosomal ribonucleic add inferred from the sequence of nuclotides in a gene

Yuen-Ling Chan, Jose Olvera and Ira G. Wool

Department of Biochemistry, University of Chicago Chicago, IL 60637, USA

Revised October 11, 1983. Accepted October 11, 1983.

The nucleotlde sequence of a rat 28S rRNA gene was determined. The 28S rRNA encoded in the gene contains 4718 nucleotides and the molecular weight estimated from the sequence Is 1.53 x 106. The guanine and cytosine content is 67%. The sequence of rat 28S rRNA diverges appreciably from that of Saccharomyces carlsbergensis 26S rRNA (about 50% identity), but more closely approximates that of Xenopus laevis 28S rRNA (about 75% identity). Rat 28S rRNA is larger than the analogous nucleic acids from yeast (3393 nucleotides) and X. laevis (4110 nucleotides) ribosomes. The additional bases are inserted in specific regions and tend to be rich in guanine and cytosine. 5.8S rRNA can interact with 28S rRNA by extensive hydrogen bonding at two sites near the 5' end of the latter.


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