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Nucleic Acids Research, 1983, Vol. 11, No. 23 8123-8136
© 1983

MOLECULAR BIOLOGY

A functional component of the sea urchin H2A gene modulator contains an extended sequence homology to a viral enhancer

Rudolf Grosschedl*, Marco Mächler, Urs Rohrer and Max L. Birnstiel

Institut für Molekularbiologie II der Universität Zürich Hönggerberg, CH-8093 Zürich, Switzerland *Massachusetts Institute of Technology, Center for Cancer Research Cambridge, MA 02139, USA

Received October 19, 1983. Accepted November 15, 1983.

The DNA sequences imparting a maximal rate of sea urchin H2A gene transcription in the frog oocyte nucleus were narrowed down by deletion mapping to a DNA segment –165 to –111, far-upstream of the H2A mRNA cap site. C to T base changes in this area create strong down mutations, hence the primary structure of this DNA sequence is of paramount importance to the H2A gene expression. Sequence comparisons suggest that the –165 to –111 region may contain two essential sequence blocks. Most strikingly, the –135 area contains a 14 out of 17 basepair homology to the Moloney murine sarcoma virus enhancer and to topologically related 5' LTR-sequences of the simian sarcoma virus and the murine Friend spleen focus forming virus.


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