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Nucleic Acids Research, 1983, Vol. 11, No. 24 8877-8890
© 1983

MOLECULAR BIOLOGY

Structural analysis of a rabbit immunoglobulin x2 J-C locus reveals multiple deletions

Laurent Emorine* and Edward E. Max+

Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20205, USA

+To whom correspondence should be addressed

Received August 29, 1983. Revised November 14, 1983. Accepted November 14, 1983.

We previously reported that domestic rabbits harbor at least two DNA sequences that hybridize strongly to immunoglobulin k C region probes in Southern blots. One of these was cloned from a domestic b4 rabbit and identified as the gene for the nominal b4 allotype k chain which is expressed at high levels. We now have cloned (from a b4 rabbit) the other homologous sequence and find that it encodes a k chain nearly identical to the k2 chain of "bas" rabbits, which is not normally expressed at detectable levels in domestic rabbits. Sequence analysis of this k2 chain reveals a Jk-Ck locus with no obvious coding sequence defects that could explain its low expression. However, several base changes in a putative enhancer region as well as deletions (totalling about 1.5 kb) in the J-C intron might be related to low expression. The comparison between these two k genes raises questions about the selective pressures operating during the evolution of this gene system.

*Current address: Laboratory of Molecular Immunology, Institut J. Monod, University Paris VII, 2 Place Jussieu 75221, Paris Cedex 05, France


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