Skip Navigation

This Article
Right arrow Print PDF (1351K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (94)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Arnott, S.
Right arrow Articles by Ratliff, R.L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arnott, S.
Right arrow Articles by Ratliff, R.L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1983, Vol. 11, No. 5 1457-1474
© 1983

CHEMISTRY

Wrinkled DNA

Struther Arnott, R. Chandrasekaran, L.C. Puigjaner, J.K. Walker, I.H. Hall, D.L. Birdsall and R.L. Ratliff

Department of Biological Sciences, Purdue University West Lafayette, IN 47907, USA Los Alamos Scientific Laboratory, University of California Los Alamos, NM 87544, USA

Received November 15, 1982. Revised February 8, 1983. Accepted February 8, 1983.

The B form of poly d(GC):poly d(GC) in orthorhombic microcrystallites in oriented fibers has a secondary structure in which a dinucleotide is the repeated motif rather than a mononucleotide as in standard, smooth B DNA. One set of nucleotides (probably GpC) has the same conformations as the smooth form but the alternate (CpG) nucleotides have a different conformation at C3'-03'. This leads to a distinctive change in the orientation of the phosphate groups. Similar perturbations can be detected in other poly d(PuPy):poly d(PuPy) DNAs such as poly d(IC):poly d(IC) and poly d(AT):poly d(AT) in their D forms which have tetragonal crystal environments. This suggests that such perturbations are intrinsic to all stretches of duplex DHA where purines and pyrimidines alternate and may play a role in the detection and exploitation of such sequences by regulatory proteins.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J BiochemHome page
S. Koide, I. Yoshida, A. Tsuji, and Y. Matsuda
The Expression of Proprotein Convertase PACE4 Is Highly Regulated by Hash-2 in Placenta: Possible Role of Placenta-Specific Basic Helix-Loop-Helix Transcription Factor, Human Achaete-Scute Homologue-2
J. Biochem., September 1, 2003; 134(3): 433 - 440.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A Mahendrasingam, V. Forsyth, R Hussain, R. Greenall, W. Pigram, and W Fuller
Time-resolved X-ray diffraction studies of the B in equilibrium D structural transition in the DNA double helix
Science, July 11, 1986; 233(4760): 195 - 197.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.