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Nucleic Acids Research, 1983, Vol. 11, No. 5 1537-1542
© 1983

MOLECULAR BIOLOGY

Complete nucleotide sequence of a cloned cDNA derived from the major adult {alpha}-globin mRNA ofX. laevis

R.M. Kay*, R. Harris, R.K. Patient+ and J.G. Williams

Imperial Cancer Research Fund, Mill Hill Laboratories, Buttonhole Lane London, NW7 IAD, UK

Received February 1, 1983. Accepted February 14, 1983.

The complete sequence of a cloned cDNA derived from the major adult {alpha}-globin mRNA of Xenopus laevis (the South African Clawed Toad) is presented. The sequence contains the complete coding and 3' non-coding regions of the mRNA and part of the 5' non-coding region. The amino acid sequence of the encoded {alpha}-globin polypeptide has been deduced and is compared to other {alpha}-globin polypeptides. We find that the sequence is equally diverged from a bullfrog tadpole {alpha}-globin polypeptide and human a-globin polypeptide suggesting that these three sequences may have diverged from a common ancestral sequence several hundred million years ago.

*Present address: Genetics Institute, 225 Langwood Avenue, Boston, MA, USA

+Present address: King's College, Department of Biophysics, 26–29 Drury Lane, London, WC2B 5RL, UK.


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