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Nucleic Acids Research, 1983, Vol. 11, No. 5 1589-1599
© 1983

CHEMISTRY

Color coded triarylmethyl protecting groups useful for deoxypolynucleotide synthesis

E.F. Fisher and M.H. Caruthers

Department of Chemistry, University of Colorado Boulder, CO 80309, USA

Received December 1, 1982. Revised February 1, 1983. Triarylmethyl groups having ditferent colors but similar chemical reactivities in acid were examined as potential aids for monitoring the stepwise addition of mononucleotides to a deoxy-oligonucleotide. The successful application of these protecting groups to deoxyoligonucleotide synthesis on polymer supports was demonstrated.


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