Skip Navigation

This Article
Right arrow Print PDF (401K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Sadler, J. R
Right arrow Articles by Smith, T. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sadler, J. R
Right arrow Articles by Smith, T. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1983, Vol. 11, No. 7 2221-2232
© 1983

MOLECULAR BIOLOGY

Regulatory pattern Identification in nucleic acid sequences

J. R Sadler1, M. S. Waterman2 and T. F. Smith3

1Dept. Biochemistry/Biophysics/Gentics, Univ. Colorado Health Sciences Center Denver, CO 80262 2Dept. Biochemistry and Biophysics, Sch. Med., Univ. California San Francisco, CA 94121 3Theoretical Biology, Los Alamos Natl. Lab., Los Alamos, NM 87545, USA

Received September 1, 1982. Revised February 28, 1983. Accepted March 1, 1983.

In addition to the sequence homologies and statistical patterns identified among numerous genetic sequences, there are subtler classes of patterns for which most current computer search methods offer very limited utility. This class includes various presumptive eukaryotic regulatory sites. A critique of the often employed consensus and local homology methods suggests the need for new tools. In particular, such new methods should use the positional and structural data now becoming available on exactly what it is that is recognized in the DNA sequence by sequence-specific binding proteins.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.