Nucleic Acids Research, 1984, Vol. 12, No. 10 4295-4311
© 1984
MOLECULAR BIOLOGY |
The TGGCA-binding protein: a eukaryotic nuclear protein recognizing a symmetrical sequence on double-stranded linear DNA
Zentrum für Molekulare Biologie der Universität Heidelberg Im Neuenheimer Feld 364, D-6900 Heidelberg, FRG
*To whom correspondence should be addressed
Received March 6, 1984. Revised April 27, 1984. Accepted April 27, 1984.
Low salt extracts of chicken oviduct nuclei contain a DNA binding protein with high affinity for specific DNA sequences in the flanking regions of the chicken lysozyme gene. Two of the three binding sites found within a total of 11 kb upstream from the promoter are located only 92 bp apart from each other. Upon comparison of the DNA binding sites, the symmetrical consensus sequence 5'-TGGCANNNTGCCA-3' can be deduced as the protein recognition site. This sequence is the central part of 23 to 25 base pairs protected by the DNA binding protein from DNAase I digestion. A homologous binding activity can be detected in nuclei from several chicken tirsues and from mouse liver.
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