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Nucleic Acids Research, 1984, Vol. 12, No. 11 4593-4608
© 1984

MOLECULAR BIOLOGY

Sequences of the E. coli uvrC gene and protein

Gwendolyn B. Sancar+,*, Aziz Sancar+ and W.Dean Rupp

Departments of Therapeutic Radiology and Molecular Biophysics and Biochemistry, Yale University School of Medicine 333 Cedar Street, New Haven, Cr 06510, USA

*To whom correspondence should be addressed

Received April 17, 1984. Accepted May 8, 1984.

We have determined the sequence of a 2400 bp region of E. coli chromosomal DNA containing the uvrC gene. The coding region of uvrc is 2267 bp in length, encodes a polypeptide with a calculated molecular weight of 66,038 daltons, and is preceded by a typical E. coli ribosome binding site. By constructing deletion derivatives we have established that a uvrC promoter lies within the 113 bp region preceding the translational start of uvrC. The codon usage in uvrC is strongly biased in favor of codons used infrequently in E. coli, which may contribute to the relatively low intracellular concentration of uvrC protein.

+Present address: Department of Biochemistry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA


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