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Nucleic Acids Research, 1984, Vol. 12, No. 13 5265-5275
© 1984

MOLECULAR BIOLOGY

Molecular footprints of human immunoglobulin gene evolution: a new sequence family

Bernhard Straubinger, Michael Pech, Kathy Mühlebach, Hans-Rainer Jaenichen, 1, Hans-Gunther Bauer and Hans G. Zachau

Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie der Universität München FRG

Received May 2, 1984. Accepted June 1, 1984.

Analysis of the human VK (ref. 2) gene locus led to the detection of a new sequence family (L sequences). Its copy number is in the range of 102 The L sequences, which are about 500 bp long, are found as part of the 3' flanking regions of a clustered set of human VKI genes but they occur also separate from the genes. Models are discussed in which L sequences are viewed as molecular footprints of amplification and transposition processes of VK genes.


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