Nucleic Acids Research, 1984, Vol. 12, No. 17 6751-6762
© 1984
MOLECULAR BIOLOGY |
Developmental regulation of albumin and 
-fetoprotein gene expression in the rat
Departments of Pathology, Biochemistry, and Biophysics and Theoretical Biology, University of Chicago Chicago IL 60637, USA
+To whom correspondence should be sent at his present address
Received May 29, 1984. Revised August 14, 1984. Accepted August 14, 1984.
Albumin and AFP comprise a developmentally regulated gene family expressed predominantly in liver and yolk sac. In this study, we have analyzed the developmental changes in the levels of transcripts in liver and yolk sac, and the methylation of the genes in yolk sac. We have previously analyzed the gene methylation in developing liver and non-expressing tissues (Kunnath and Locker, 1983, EMBO J., 2, 317–324). From these analyses we can distinguish 3 active modes of coordinated expression. The adult liver synthesizes albumin, the yolk sac synthesizes AFP, and the fetal liver synthesizes both. In the yolk sac, the relatively inactive albumin gene is hypermethylated, while the active AFP gene is undermethylated. Our data suggest that the genes are activated simultaneously but that subsequent enhancement is specific for tissue and developmental stage.
*Present address: School of Medicine, Department of Pathology, University of Pittsburgh, 777A Scaife Hall, Pittsburgh, PA 15261, USA
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